Drulovic, J. (55886929900)J. (55886929900)DrulovicPekmezovic, T. (7003989932)T. (7003989932)PekmezovicMatejic, B. (9840705300)B. (9840705300)MatejicMesaros, S. (7004307592)S. (7004307592)MesarosManigoda, M. (15842202300)M. (15842202300)ManigodaDujmovic, I. (6701590899)I. (6701590899)DujmovicStojsavljevic, N. (6603086728)N. (6603086728)StojsavljevicKocev, N. (6602672952)N. (6602672952)KocevGavric-Kezic, M. (15841566100)M. (15841566100)Gavric-KezicNikic, P. (26433763500)P. (26433763500)NikicDragojlovic, M. (15841478000)M. (15841478000)Dragojlovic2025-07-022025-07-022007https://doi.org/10.1111/j.1600-0404.2006.00729.xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33846860823&doi=10.1111%2fj.1600-0404.2006.00729.x&partnerID=40&md5=d9cb1f4148d8c208fa5197e931f978d2https://remedy.med.bg.ac.rs/handle/123456789/14348Objectives - The aim of this investigation was to evaluate factors that might influence the health-related quality of life (HRQoL) in multiple sclerosis (MS) patients in Serbia. Materials and methods - This cross-sectional study was performed on a group of 156 patients with MS. HRQoL was assessed by using the SF-36 questionnaire. Expanded Disability Status Scale (EDSS) and Beck Depression Inventory (BDI) scale were assessed as variables affecting the HRQoL of MS patients. Results - EDSS score correlated negatively with all SF-36 health dimensions, and the highest statistically significant coefficients were for physical functioning (r = -0.682), and social and role functioning (r = -0.407 and -0.405 respectively). BDI correlated statistically significantly negatively (P < 0.01) with all SF-36 health dimensions. Conclusions - Our findings suggest that both disability and depression significantly influence the HRQoL in Serbian MS patients, with depressive symptoms having the major influence. © 2007 The Authors.Multiple sclerosisQuality of lifeSF-36 questionnaire