Acimovic, Milena (57188112400)Milena (57188112400)AcimovicVidakovic, Snezana (9434348100)Snezana (9434348100)VidakovicMilic, Natasa (7003460927)Natasa (7003460927)MilicJeremic, Katarina (6701486495)Katarina (6701486495)JeremicMarkovic, Milos (7101935774)Milos (7101935774)MarkovicMilosevic-Djeric, Ana (56644849100)Ana (56644849100)Milosevic-DjericLazovic-Radonjic, Gordana (57188341300)Gordana (57188341300)Lazovic-Radonjic2025-06-122025-06-122016https://doi.org/10.1515/jomb-2015-0005https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961308960&doi=10.1515%2fjomb-2015-0005&partnerID=40&md5=05d6fddba27b5db82b9c0401ac85693ehttps://remedy.med.bg.ac.rs/handle/123456789/8049Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher's, Student's t-test or the Mann - Whitney test. Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p<0.001, p=0.025 and p=0.009, respectively). False negative TVU findings were noted in 3/13 patients (23.1%) with peritoneal endometriosis without ovaries involvement. High sensitivity (93.3%), specificity (90.0%), PPV (96.6%), NPV (81.8%) and accuracy (92.5%) were obtained for a diagnostic score based on TVU and significant peripheral blood markers (CA125, survivin and VEGF). Conclusions: Determination of serum CA125, mRNA expression levels for survivin and VEGF along with TVU can contribute to higher accuracy of the noninvasive diagnostic tools for endometriosis. © by Milena Acimovic 2016.CA125endometriosislaparoscopysurvivintransvaginal ultrasoundVEGF