Skiljevic, Dusan (23487265400)Dusan (23487265400)SkiljevicNikolic, Milos M. (56910382000)Milos M. (56910382000)NikolicMilinkovic, Mirjana (57218644212)Mirjana (57218644212)MilinkovicBonaci-Nikolic, Branka (10839652200)Branka (10839652200)Bonaci-Nikolic2025-06-132025-06-132006https://www.scopus.com/inward/record.uri?eid=2-s2.0-33749619549&partnerID=40&md5=009014ae4a37695fce0f11394feae4dchttps://remedy.med.bg.ac.rs/handle/123456789/10878Originally believed to be of histiocytic origin, regressing primary cutaneous anaplastic large-cell lymphoma is a CD30 (Ki 1) positive T-cell lymphoma with histologic high grade malignancy, but with an often favorable clinical course with regression of individual lesions. We present a case of a 69-year-old white woman with an 8-month history of noduloulcerative lesions on her right lower leg, otherwise in good general health. The clinical, histologic, and immunohistochemical findings pointed to CD30 positive primary cutaneous anaplastic large-cell lymphoma. There were no signs of generalization, lymph node or internal organ involvement. After 2 years of activity, the disease regressed. During the 10-year follow-up period, no signs of disease reactivation were noted. Accurate recognition of this lymphoma is important to avoid unnecessary aggressive treatments.CD30 positiveLarge cell lymphomaRegressingSkin