Salinger-Martinovic, Sonja (15052251700)Sonja (15052251700)Salinger-MartinovicDimitrijevic, Zorica (35331704600)Zorica (35331704600)DimitrijevicStanojevic, Dragana (58530775100)Dragana (58530775100)StanojevicMomčilović, Stefan (56856733800)Stefan (56856733800)MomčilovićKostic, Tomislav (26023450500)Tomislav (26023450500)KosticKoracevic, Goran (24341050000)Goran (24341050000)KoracevicSubotic, Bojana (57191374758)Bojana (57191374758)SuboticDzudovic, Boris (55443513300)Boris (55443513300)DzudovicStefanovic, Branislav (57210079550)Branislav (57210079550)StefanovicMatijasevic, Jovan (35558899700)Jovan (35558899700)MatijasevicMiric, Milica (57193772097)Milica (57193772097)MiricMarkovic-Nikolic, Natasa (57211527501)Natasa (57211527501)Markovic-NikolicNikolic, Maja (57206239238)Maja (57206239238)NikolicMiloradovic, Vladimir (8355053500)Vladimir (8355053500)MiloradovicKos, Ljiljana (57206257234)Ljiljana (57206257234)KosKovacevic-Preradovic, Tamara (21743080300)Tamara (21743080300)Kovacevic-PreradovicSrdanovic, Ilija (6506056556)Ilija (6506056556)SrdanovicStanojevic, Jelena (57835447100)Jelena (57835447100)StanojevicObradovic, Slobodan (6701778019)Slobodan (6701778019)Obradovic2025-06-122025-06-122020https://doi.org/10.1016/j.ijcard.2019.12.025https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076826149&doi=10.1016%2fj.ijcard.2019.12.025&partnerID=40&md5=2c959329cdd203379a73abc170502ab8https://remedy.med.bg.ac.rs/handle/123456789/5016Background: Acute pulmonary embolism (PE), due to hemodynamic disturbances, may lead to multi-organ damage, including acute renal dysfunction. The aim of our study was to investigate the predictive role of renal dysfunction at admission regarding the short-term mortality and bleeding risk in hospitalized PE patients. Methods: The retrospective cohort study included 1330 consecutive patients with PE. The glomerular filtration rate (GFR) was calculated using the serum creatinine value and Cocroft-Gault formula, at hospital admission. Primary outcomes were all-cause mortality and PE-related mortality in the 30 days following admission, as well as major bleeding events. Results: Based on the estimated GFR, patients were divided into three groups: the first with GFR < 30 mL/min, the second with GFR 30–60 mL/min, and the third group with GFR > 60 mL/min. A multivariable analysis showed that GFR at admission was strongly associated with all-cause death, as well as with death due to PE. Patients in the first and second group had a significantly higher risk of 30-day all-cause mortality (HR 7.109, 95% CI 4.243–11.911, p < 0.001; HR 2.554, 95% CI 1.598–4.081, p < 0.001). Fatal bleeding was recorded in 1.6%, 0.5% and 0.8% of patients in the first, second and in the third group (p < 0.05). There were no significant differences regarding major bleeding rates among the groups. Conclusion: Renal dysfunction at admission in patients with acute pulmonary embolism is strongly associated with overall PE mortality. © 2019 Elsevier B.V.BleedingPrognosisPulmonary embolismRenal dysfunction