A rare case and literature review of bullous pemphigoid appearing in the setting of lichen sclerosus: a dermatopathological conundrum and what to expect

Orlić, Tijana (58783605700)Tijana (58783605700)OrlićKapetanović, Igor (57219221867)Igor (57219221867)KapetanovićReljić, Vesna (55895308600)Vesna (55895308600)ReljićMinić, Snežana (35409907200)Snežana (35409907200)MinićŽivanović, Dubravka (24170307900)Dubravka (24170307900)Živanović2025-06-122025-06-122024https://doi.org/10.15570/actaapa.2024.30https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208481575&doi=10.15570%2factaapa.2024.30&partnerID=40&md5=18be26c8e8091f5c01099fcdc8e72240https://remedy.med.bg.ac.rs/handle/123456789/1298Co-occurrence of blisters in patients with lichen sclerosus (LS) can raise the question of whether they represent a bullous variant of LS or a concomitant autoimmune disorder. We report a rare case of bullous pemphigoid (BP) occurring on previous LS lesions. To the best of our knowledge, this is also the first BP180-negative case reported in literature. Here, we propose alternative mechanisms, independent of BP autoantibodies, that may lead to development of BP on skin affected by LS. In addition, we provide a literature review that explores the underlying pathophysiology and offers practical treatment insights, equipping clinicians with valuable guidance for similar complex cases. © 2024, Association of Slovenian Dermatovenerologists. All rights reserved.autoimmune diseasesBP180 antigenbullous pemphigoiddermatopathologylichen sclerosusA rare case and literature review of bullous pemphigoid appearing in the setting of lichen sclerosus: a dermatopathological conundrum and what to expect