Dujmović, I. (6701590899)I. (6701590899)DujmovićMesaroš, Š. (7004307592)Š. (7004307592)MesarošPekmezović, T. (7003989932)T. (7003989932)PekmezovićLević, Z. (7003341242)Z. (7003341242)LevićDrulović, J. (55886929900)J. (55886929900)Drulović2025-07-022025-07-022004https://doi.org/10.1111/j.1468-1331.2004.00797.xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-3843069960&doi=10.1111%2fj.1468-1331.2004.00797.x&partnerID=40&md5=1594c11034af748687c3538cb4df9d9ehttps://remedy.med.bg.ac.rs/handle/123456789/14450The aim of our study was to analyse clinical and paraclinical characteristics of patients with multiple sclerosis (MS) with previous diagnosis of primary-progressive (PP) MS according to the Poser's criteria and further investigate if they fulfil the McDonald's diagnostic criteria for this disorder. A total of 561 MS patients were registered in the database at the Institute of Neurology, Belgrade, from 1 January 1997 to 31 December 2000 and 63 of them (11.2%) with previous diagnosis of PPMS were analysed retrospectively. Male/female ratio was 1.3:1 and mean age at onset 33.2 years. Most frequent at onset were pyramidal (in 73% of patients) and sensory symptoms (in 41% of patients); 74.6% of patients had greater than or equal to nine brain magnetic resonance imaging (MRI) lesions. Intrathecal oligoclonal immunoglobulin G (IgG) was detected in 96.7% and prolonged visual evoked potentials (VEP) P100 latency in 82.4% of patients. Of the total study group of 561 patients, 10.2% fulfilled the recently recommended McDonald's diagnostic criteria for the diagnosis of PPMS. Our findings further support the significance of the brain/spinal cord MRI, cerebrospinal fluid and VEP findings for precise diagnostic assessment in patients with suspected PP form of MS.Disease onsetMagnetic resonance imagingMale genderMultiple sclerosisOligoclonal IgGPrimary progressivePyramidal symptomsVisual evoked potentials