Suvakov, Sonja (36572404500)Sonja (36572404500)SuvakovJerotic, Djurdja (57209718540)Djurdja (57209718540)JeroticDamjanovic, Tatjana (6603050029)Tatjana (6603050029)DamjanovicMilic, Natasa (7003460927)Natasa (7003460927)MilicPekmezovic, Tatjana (7003989932)Tatjana (7003989932)PekmezovicDjukic, Tatjana (36193753800)Tatjana (36193753800)DjukicJelic-Ivanovic, Zorana (6603775254)Zorana (6603775254)Jelic-IvanovicSavic Radojevic, Ana (16246037100)Ana (16246037100)Savic RadojevicPljesa-Ercegovac, Marija (16644038900)Marija (16644038900)Pljesa-ErcegovacMatic, Marija (58618962300)Marija (58618962300)MaticMcclements, Lana (55600912900)Lana (55600912900)McclementsDimkovic, Nada (6603958094)Nada (6603958094)DimkovicGarovic, Vesna D. (6603419874)Vesna D. (6603419874)GarovicAlbright, Robert C. (7005097444)Robert C. (7005097444)AlbrightSimic, Tatjana (6602094386)Tatjana (6602094386)Simic2025-06-122025-06-122019https://doi.org/10.1159/000501300https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068526930&doi=10.1159%2f000501300&partnerID=40&md5=2e27592ee054836685b9320ca8968050https://remedy.med.bg.ac.rs/handle/123456789/5531Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p < 0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups. © 2019 © 2019 S. Karger AG, Basel. Copyright: All rights reserved.Endothelial dysfunctionGene polymorphismHaemodialysisOxidative stressSurvival analysis