Zelenak, Christine (36873788500)Christine (36873788500)ZelenakChavanon, Mira-Lynn (14048024000)Mira-Lynn (14048024000)ChavanonTahirovic, Elvis (24339336300)Elvis (24339336300)TahirovicTrippel, Tobias Daniel (16834210300)Tobias Daniel (16834210300)TrippelTscholl, Verena (54982696400)Verena (54982696400)TschollStroux, Andrea (10139008600)Andrea (10139008600)StrouxVeskovic, Jovan (56951285600)Jovan (56951285600)VeskovicApostolovic, Svetlana (13610076800)Svetlana (13610076800)ApostolovicObradovic, Danilo (35731962400)Danilo (35731962400)ObradovicZdravkovic, Marija (24924016800)Marija (24924016800)ZdravkovicLoncar, Goran (55427750700)Goran (55427750700)LoncarStörk, Stefan (6603842450)Stefan (6603842450)StörkHerrmann-Lingen, Christoph (6603417225)Christoph (6603417225)Herrmann-LingenDüngen, Hans-Dirk (16024171900)Hans-Dirk (16024171900)Düngen2025-06-122025-06-122019https://doi.org/10.2217/bmm-2019-0083https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074446572&doi=10.2217%2fbmm-2019-0083&partnerID=40&md5=3cbd5157c1353ee1eed5e25a80c4cec1https://remedy.med.bg.ac.rs/handle/123456789/5805Aim: Heart failure negatively impacts quality of life (QoL), which in turn contributes to an adverse long-term prognosis. We aimed at identifying biomarker trajectories after an episode of acutely decompensated heart failure (ADHF) that differ between patients showing average versus impaired QoL 1 year later, thus allowing to predict impaired QoL. Methods: Biomarkers were repeatedly measured throughout the year in 104 ADHF patients. QoL was assessed at discharge and 1 year after ADHF. Logistic regression and receiver operating characteristic analyses were used to identify predictors of impaired QoL while controlling psychosocial confounders. Results: MR-proANP predicted impaired physical and mental QoL. NT-proBNP measurements were important predictors for poor physical QoL. Conclusion: MR-proANP and NT-proBNP predict poor QoL after an epidode of ADHF. The trial is registered at http://clinicaltrials.gov as MOLITOR (IMpact of therapy optimisation On the Level of biomarkers in paTients with Acute and Decompensated ChrOnic HeaRt Failure) with unique identifier: NCT01501981. © 2019 Future Medicine Ltd.ADHFdisease managementheart failureMR-proANPNT-proBNPpredictionQoLsupport