Ypsilantis, Petros (6603429809)Petros (6603429809)YpsilantisLambropoulou, Maria (56234594400)Maria (56234594400)LambropoulouKarayiannakis, Anastasios (57202315331)Anastasios (57202315331)KarayiannakisMilicevic, Miroslav (7005565664)Miroslav (7005565664)MilicevicBulajic, Predrag (35615774800)Predrag (35615774800)BulajicZacharoulis, Dimitrios (6603328970)Dimitrios (6603328970)ZacharoulisSioka, Eleni (22939197200)Eleni (22939197200)SiokaSimopoulos, Constantinos (35452248900)Constantinos (35452248900)Simopoulos2025-07-022025-07-022017https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037176039&partnerID=40&md5=fcfa23df69b43de4b1349439cd923946https://remedy.med.bg.ac.rs/handle/123456789/13066Purpose: To evaluate remnant liver tissue damage in a pig model of radiofrequency (RF)-assisted liver resection employing either the sequential coagulate cut (SCC) Belgrade technique using a monopolar RF electrode or the one using the bipolar Habib-4x device. Methods: Sixteen pigs underwent either a) resection of part of the left lateral and left median hepatic lobes employing the SCC (SCC group), the Habib-4X (H group) or the “crush-clamp” technique (CC group) or b) sham operation (Sham group). Forty-eight hours later, tissue specimens were excised from the right lateral hepatic lobe for histopathological examination and immunohistochemical assessment of tissue injury, mitosis and inflammation. Results: Histopathologic lesions, apoptotic activity, HSP 40 and TNF? expression were more intense, while mitotic activity was less prominent in the SCC group technique compared to H group. Comparison between CC and H groups suggested the pivotal role of partial hepatectomy (PH) per se in the changes noted in H group. Conclusion: The Habib-4X liver resection technique proved to be less injurious in the remnant liver tissue after PH compared to the SCC technique. © 2017 Zerbinis Publications. All rights reserved.LiverLiver resectionRadiofrequencyTissue injury