Radlović, Nedeljko (24169188700)Nedeljko (24169188700)RadlovićLeković, Zoran (8319022100)Zoran (8319022100)LekovićMladenović, Marija (24330002200)Marija (24330002200)MladenovićVuletić, Biljana (25121846900)Biljana (25121846900)VuletićRadlović, Jelena (57212675165)Jelena (57212675165)RadlovićDučić, Siniša (22950480700)Siniša (22950480700)DučićNikolić, Dejan (26023650800)Dejan (26023650800)Nikolić2025-06-122025-06-122023https://doi.org/10.2298/SARH230716098Rhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85184922360&doi=10.2298%2fSARH230716098R&partnerID=40&md5=7a5cecc2ef740dedae56c8d89f94c83dhttps://remedy.med.bg.ac.rs/handle/123456789/1940Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye, and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5–15%), very heterogeneous expression and frequent association with other autoimmune diseases (3–10%), as well as selective deficiency of IgA and Down, Turner, and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong gluten-free diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis. © 2023, Serbia Medical Society. All rights reserved.celiac diseaseclinical formsdiagnosticspathogenesis