Veličković, Jelena (29567657500)Jelena (29567657500)VeličkovićVukičević, Tatjana Adžić (59158046400)Tatjana Adžić (59158046400)VukičevićSpurnić, Aleksandra Radovanović (36457278400)Aleksandra Radovanović (36457278400)SpurnićLazić, Igor (57209263230)Igor (57209263230)LazićPopović, Bojana (36127992300)Bojana (36127992300)PopovićBogdanović, Ivan (55376410100)Ivan (55376410100)BogdanovićRaičević, Savo (56176851100)Savo (56176851100)RaičevićMarić, Dragana (57196811444)Dragana (57196811444)MarićBerisavac, Ivana (6507392420)Ivana (6507392420)Berisavac2025-06-122025-06-122022https://doi.org/10.3389/fmed.2022.973817https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137816866&doi=10.3389%2ffmed.2022.973817&partnerID=40&md5=b107138bb85335040e033f52eaf73a68https://remedy.med.bg.ac.rs/handle/123456789/3368Coronavirus disease (COVID-19) in immunocompromised patients represents a major challenge for diagnostics, surveillance, and treatment. Some individuals remain SARS-CoV-2 PCR-positive for a prolonged period. The clinical and epidemiological significance of this phenomenon is not well understood. We report a case of a patient with a history of systemic lupus erythematosus (SLE) who has been persistently SARS-CoV-2 PCR positive for 9 months, with multiple thromboembolic complications, and development of nocardial brain abscess successfully treated with surgery and antibiotics. Copyright © 2022 Veličković, Vukičević, Spurnić, Lazić, Popović, Bogdanović, Raičević, Marić and Berisavac.brain abscessCOVID-19immunosuppressionNocardiaSARS-CoV-2systemic lupus erythematosus