Mladenović, Dušan (36764372200)Dušan (36764372200)MladenovićHrnčić, Dragan (13907639700)Dragan (13907639700)HrnčićRadosavljević, Tatjana (6603466847)Tatjana (6603466847)RadosavljevićVučević, Danijela (55881342600)Danijela (55881342600)VučevićDjurić, Dragan (36016317400)Dragan (36016317400)DjurićRašić-Marković, Aleksandra (23480382100)Aleksandra (23480382100)Rašić-MarkovićMacut, Djuro (35557111400)Djuro (35557111400)MacutŠušić, Veselinka (7003269321)Veselinka (7003269321)ŠušićŠćepanović, Ljiljana (6506067087)Ljiljana (6506067087)ŠćepanovićStanojlović, Olivera (6602159151)Olivera (6602159151)Stanojlović2025-06-122025-06-122008https://doi.org/10.1139/Y08-009https://www.scopus.com/inward/record.uri?eid=2-s2.0-42149185578&doi=10.1139%2fY08-009&partnerID=40&md5=f20aa9ef2c4fa7b85994c3fe86e048b6https://remedy.med.bg.ac.rs/handle/123456789/10752Chronic ethanol consumption is a major risk factor for epilepsy, and seizures frequently occur during the withdrawal period. The aim of our study was to investigate effects of ethanol on lindane-induced seizures in rats. Male Wistar rats were injected i.p. with one of the following 5 treatments: (i) saline, (ii) dimethylsulfoxide, (iii) lindane (8 mg/kg) (L), (iv) ethanol in doses of 0.5 g/kg (E0.5), 1 g/kg (E1), and 2 g/kg (E 2), and (v) groups that received ethanol 30 min before lindane (LE0.5, LE1, and LE2). Behavioral changes were described by using a descriptive scale as follows: 0, no response; 1, head nodding, lower jaw twitching; 2, myoclonic body jerks, bilateral forelimb clonus; 3, generalized tonic-clonic convulsions; 4, status epilepticus. The incidence of convulsions in the LE2 group was significantly lower than the incidence in the L (p < 0.01) and LE0.5 groups (p < 0.05). The median grade of convulsive behavior was significantly lower in the LE2 (p < 0.01) and LE1 groups (p < 0.05) compared with the L group. Latencies to the first seizure response were not significantly different among groups. ED50 of ethanol was 1.40 (1.19-1.65). Our findings suggest that ethanol decreased severity and incidence of lindane-induced seizures in a dose-dependent manner. © 2008 NRC Canada.Dose-dependent effectEthanolLindaneRatsSeizures