Radojicic, Zoran (12768612400)Zoran (12768612400)RadojicicMilivojevic, Sasa (57202783337)Sasa (57202783337)MilivojevicKoricanac, Irena (57209261029)Irena (57209261029)KoricanacLazovic, Jelena Milin (57023980700)Jelena Milin (57023980700)LazovicLaketic, Darko (25936376800)Darko (25936376800)LaketicRadojicic, Ognjen (57223969149)Ognjen (57223969149)RadojicicMilic, Natasa (7003460927)Natasa (7003460927)Milic2025-06-122025-06-122021https://doi.org/10.1186/s12887-021-02714-zhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85106653946&doi=10.1186%2fs12887-021-02714-z&partnerID=40&md5=dc40f2dbcbd11d8d750c1d1d18fa9539https://remedy.med.bg.ac.rs/handle/123456789/3872Aims: To evaluate the impact of compliance on the therapeutic effects of Desmopressin, as well as the importance of establishing the voiding school for low-compliance children in primary monosymptomatic enuresis treatment. Methods: Eighty-nine patients with primary monosymptomatic enuresis treated with Desmopressin were observed during the 2017–2020 at University Children’s Hospital Belgrade, Serbia. The average patients age was 7.7 ± 2.4 years; 65 (73%) were boys and 24 (27%) % were girls. After the 3 months of Desmopressin treatment, the effect of therapy was evaluated according to the compliance. After the treatment, low-compliance patients and their parents were suggested to visit a voiding school. Results: A significant decrease in the median enuresis frequency was noticed during the Desmopressin treatment (25.0 (20.0–26.0) vs 10.0 (2.0–17.0) per month, before vs after treatment, respectively) (p < 0.001). Patients with low compliance had a poorer response to Desmopressin (p < 0.001). An median enuresis reduction in the good compliance group was 92.3% (86.7 -95%), while in the low compliance group was 28.6% (16.7–43.3%). After attending voiding school, there was a significant increase in compliance (p < 0.001), associated with an median percent decrease in enuresis of 84.0% (75.0–95.5%) (p < 0.001). Conclusion: Compliance considerably influences the beneficial effects of Desmopressin. Patients with poor therapeutic effects should be evaluated for compliance and introduced to voiding school. © 2021, The Author(s).ChildrenComplianceDesmopressinPrimary Monosymptomatic nocturnal enuresisVoiding school