Ostojic, Sergej M. (8552029600)Sergej M. (8552029600)OstojicOstojic, Jelena (12797904900)Jelena (12797904900)OstojicDrid, Patrik (57209794562)Patrik (57209794562)DridVranes, Milan (16246559800)Milan (16246559800)Vranes2025-07-022025-07-022016https://doi.org/10.1139/apnm-2016-0178https://www.scopus.com/inward/record.uri?eid=2-s2.0-84985898275&doi=10.1139%2fapnm-2016-0178&partnerID=40&md5=23d4bdbba7880540675417309ddfccc5https://remedy.med.bg.ac.rs/handle/123456789/13374In this randomized, double-blind, crossover trial, we evaluated whether 4-week supplementation with guanidinoacetic acid (GAA) is superior to creatine in facilitating creatine levels in healthy men (n = 5). GAA (3.0 g/day) resulted in a more powerful rise (up to 16.2%) in tissue creatine levels in vastus medialis muscle, middle-cerebellar peduncle, and paracentral grey matter, as compared with creatine (P < 0.05). These results indicate that GAA as a preferred alternative to creatine for improved bioenergetics in energy-demanding tissues. © 2016, Canadian Science Publishing. All right reserved.BioenergeticsCerebellumHomocysteineVastus medialis muscle