Kostić, Vladimir S. (35239923400)Vladimir S. (35239923400)KostićPekmezović, Tatjana (7003989932)Tatjana (7003989932)PekmezovićTomić, Aleksandra (26654535200)Aleksandra (26654535200)TomićJečmenica-Lukić, Milica (35801126700)Milica (35801126700)Ječmenica-LukićStojković, Tanja (57211211787)Tanja (57211211787)StojkovićŠpica, Vladana (55324145700)Vladana (55324145700)ŠpicaSvetel, Marina (6701477867)Marina (6701477867)SvetelStefanova, Elka (7004567022)Elka (7004567022)StefanovaPetrović, Igor (7004083314)Igor (7004083314)PetrovićDžoljić, Eleonora (6603126705)Eleonora (6603126705)Džoljić2025-07-022025-07-022010https://doi.org/10.1016/j.jns.2009.08.016https://www.scopus.com/inward/record.uri?eid=2-s2.0-74149092235&doi=10.1016%2fj.jns.2009.08.016&partnerID=40&md5=196431994cef770503024e7fc1d7fce1https://remedy.med.bg.ac.rs/handle/123456789/14245Little is known about the prevalence and correlates of suicidal behavior in Parkinson's disease (PD). In the first part of the study, we followed a cohort of 102 consecutive PD patients for 8 years and found that the suicide-specific mortality was 5.3 (95% CI 2.1-12.7) times higher than expected. In the second part, we tested 128 PD patients for death and suicidal ideation and administered an extensive neurological, neuropsychological and psychiatric battery. Current death and/or suicidal ideation was registered in 22.7%. On univariate logistic regression analysis, psychiatric symptoms (depression, but also anxiety and hopelessness), but not the PD-related variables, were associated with such ideation. On multivariate logistic regression analysis this association held for major depression (odds ratio = 4.6; 95% CI 2.2-9.4; p < 0.001), psychosis (odds ratio = 19.2; 95% CI 1.4-27.3; p = 0.026), and increasing score of the Beck Hopelessness Scale (odds ratio = 1.2; 95% CI 1.0-1.4; p = 0.008). In conclusion, the suicide risk in PD may not be as high as it is expected, but it is certainly not trivial. According to our data almost a quarter of PD patients had death and/or suicidal ideation, that may significantly influence their quality of life. © 2009 Elsevier B.V. All rights reserved.DepressionParkinson's diseaseSuicidal behavior