Okic-Djordjevic, Ivana (55749320000)Ivana (55749320000)Okic-DjordjevicTrivanovic, D. (54421475000)D. (54421475000)TrivanovicKrstic, J. (26532883400)J. (26532883400)KrsticJaukovic, A. (7006010128)A. (7006010128)JaukovicMojsilovic, S. (14036036900)S. (14036036900)MojsilovicSantibanez, J.F. (56544274300)J.F. (56544274300)SantibanezTerzic, M. (55519713300)M. (55519713300)TerzicVesovic, D. (57215737658)D. (57215737658)VesovicBugarski, D. (35616659100)D. (35616659100)Bugarski2025-06-122025-06-122013https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879592748&partnerID=40&md5=db29845efc96b839e67c07abfd008a16https://remedy.med.bg.ac.rs/handle/123456789/9084Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.Antiproliferative effectBreast cancerColon cancerDietary supplement GE132+NaturalProstate cancer