Crnošija, Luka (55943212800)Luka (55943212800)CrnošijaKrbot Skorić, Magdalena (55915654300)Magdalena (55915654300)Krbot SkorićAndabaka, Marko (57207949404)Marko (57207949404)AndabakaJunaković, Anamari (55252791400)Anamari (55252791400)JunakovićMartinović, Vanja (56925159700)Vanja (56925159700)MartinovićIvanović, Jovana (57196371316)Jovana (57196371316)IvanovićMesaroš, Šarlota (7004307592)Šarlota (7004307592)MesarošPekmezović, Tatjana (7003989932)Tatjana (7003989932)PekmezovićDrulović, Jelena (55886929900)Jelena (55886929900)DrulovićHabek, Mario (14050219000)Mario (14050219000)Habek2025-07-022025-07-022020https://doi.org/10.1177/1352458519837703https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063347775&doi=10.1177%2f1352458519837703&partnerID=40&md5=862e1a8696148085d6ddabdad9da1434https://remedy.med.bg.ac.rs/handle/123456789/12477Aims: To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS). Design/Methods: Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. The quantification of cardiovascular autonomic dysfunction (CAD) was made using the two indices of the Composite Autonomic Scoring Scale (CASS): adrenergic index (AI) and cardiovagal index (CI). Results: In all pwNMOSD, COMPASS-31 was >0. Sympathetic dysfunction was present in 8 (40%), parasympathetic dysfunction in 10 (50%), and orthostatic hypotension in 6 (30%) pwNMOSD. This group of patients had higher frequency and level on the pupillomotor domain of the COMPASS-31 compared to pwMS (p = 0.048 and p = 0.006, respectively). A binary logistic regression model showed that drop in diastolic blood pressure (dBP) during tilt-table test and normal function of autonomic nervous system, defined as AI = 0 and CI = 0, were independent predictors of pwNMOSD (p = 0.042 and p = 0.029, respectively). If CAD was present, it was significantly worse in pwNMOSD compared to pwMS (p = 0.003). Conclusion: Significant proportion of pwNMOSD experience dysautonomia, which seems to be different from dysautonomia observed in pwMS. © The Author(s), 2019.autonomic dysfunctionmultiple sclerosisNeuromyelitis optica spectrum disorders