Browsing by Author "Haehling, Stephan Von (6602981479)"

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The β-blocker uptitration in elderly with heart failure regarding biomarker levels: CIBIS-ELD substudy
(2018)
Cvetinovic, Natasa (55340266600)
;
Sekularac, Nikola (23981224200)
;
Haehling, Stephan Von (6602981479)
;
Tahirovic, Elvis (24339336300)
;
Inkrot, Simona (35784615000)
;
Lainscak, Mitja (9739432000)
;
Apostolovic, Svetlana (13610076800)
;
Putnikovic, Biljana (6602601858)
;
Waagstein, Finn (56216780700)
;
Gelbrich, Goetz (14119833600)
;
Aleksic, Andja (57206730766)
;
Loncar, Goran (55427750700)
;
Düngen, Hans-Dirk (16024171900)
Aim: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure. Patients & methods: According to the biomarkers’ levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. Results: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of β-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. Conclusion: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration. C 2018 Future Medicine Ltd
Some of the metrics are blocked by your
consent settings
The β-blocker uptitration in elderly with heart failure regarding biomarker levels: CIBIS-ELD substudy
(2018)
Cvetinovic, Natasa (55340266600)
;
Sekularac, Nikola (23981224200)
;
Haehling, Stephan Von (6602981479)
;
Tahirovic, Elvis (24339336300)
;
Inkrot, Simona (35784615000)
;
Lainscak, Mitja (9739432000)
;
Apostolovic, Svetlana (13610076800)
;
Putnikovic, Biljana (6602601858)
;
Waagstein, Finn (56216780700)
;
Gelbrich, Goetz (14119833600)
;
Aleksic, Andja (57206730766)
;
Loncar, Goran (55427750700)
;
Düngen, Hans-Dirk (16024171900)
Aim: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure. Patients & methods: According to the biomarkers’ levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. Results: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of β-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. Conclusion: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration. C 2018 Future Medicine Ltd